Location- and Frequency-Dependent Effects of Thalamic Temporal Interference Stimulation During Sleep
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorUniversity of Wisconsin, Madison
About this trial
This study is to find out whether a type of non-invasive electrical brain stimulation called temporal interference transcranial electrical stimulation (TI-TES) can temporarily change brain activity during sleep, especially sleep spindles (brain rhythms in the \~8-16 Hz range). Up to 24 healthy participants in Dane County, Wisconsin will be enrolled for 3 overnight study visits. Participants can expect to be on study for approximately 5 weeks, depending on scheduling availability.
Eligibility criteria
Qualifiers
Medically healthy (based on self-report and study team review)
U.S. citizen or holding permanent resident status
English-speaking (able to provide consent and complete questionnaires)
Disqualifiers
Any current or past history of neurological disorders or acquired neurological disease (e.g. stroke, traumatic brain injury), including intracranial lesions (including clinically significant findings identified in first MRI)
History of inpatient psychiatric hospitalization
History of head trauma resulting in prolonged loss of consciousness; or a history of greater than 3 grade I concussions
Current history of poorly controlled headaches including intractable or poorly controlled migraines
Trial design
Treatments tested in this trial
- Magnetic Resonance Imaging (MRI)
- Broad thalamic stimulation (TI-TES)
- Carrier only SHAM stimulation
- Anterior thalamic stimulation (TI-TES)
- Posterior thalamic stimulation (TI-TES)
Treatment groups
24 Participants
are divided into 1 treatment groupSponsors and collaborators
University of Wisconsin, Madison
Lead sponsor
National Institute of Mental Health (NIMH)
Collaborator
Source ClinicalTrials.gov