Location- and Frequency-Dependent Effects of Thalamic Temporal Interference Stimulation During Sleep

ConditionsHealthy Adult Participants Healthy Participants

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-40

SponsorUniversity of Wisconsin, Madison

About this trial

This study is to find out whether a type of non-invasive electrical brain stimulation called temporal interference transcranial electrical stimulation (TI-TES) can temporarily change brain activity during sleep, especially sleep spindles (brain rhythms in the \~8-16 Hz range). Up to 24 healthy participants in Dane County, Wisconsin will be enrolled for 3 overnight study visits. Participants can expect to be on study for approximately 5 weeks, depending on scheduling availability.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Medically healthy (based on self-report and study team review)

U.S. citizen or holding permanent resident status

English-speaking (able to provide consent and complete questionnaires)

Disqualifiers

Any current or past history of neurological disorders or acquired neurological disease (e.g. stroke, traumatic brain injury), including intracranial lesions (including clinically significant findings identified in first MRI)

History of inpatient psychiatric hospitalization

History of head trauma resulting in prolonged loss of consciousness; or a history of greater than 3 grade I concussions

Current history of poorly controlled headaches including intractable or poorly controlled migraines

Trial design

Design model

Single group

Treatments tested in this trial

Magnetic Resonance Imaging (MRI)
Other intervention
MRI is to optimize placement of multipolar TI-TES
Broad thalamic stimulation (TI-TES)
Device
Stimulation targeted at the whole thalamus. Within each overnight session, up to 24 stimulation protocols will be administered, randomized across frequencies (including SHAM). Stimulation will be initiated by trained sleep technicians during stable N2 sleep and delivered in 3-minute epochs separated by 6-minute intervals to enable comparison of PRE, STIM, and POST intervals
Carrier only SHAM stimulation
Device
Carrier only SHAM condition. Within each overnight session, up to 24 stimulation protocols will be administered, randomized across frequencies (including SHAM). Stimulation will be initiated by trained sleep technicians during stable N2 sleep and delivered in 3-minute epochs separated by 6-minute intervals to enable comparison of PRE, STIM, and POST intervals
Anterior thalamic stimulation (TI-TES)
Device
Stimulation targeted at the anterior thalamus. Within each overnight session, up to 24 stimulation protocols will be administered, randomized across frequencies (including SHAM). Stimulation will be initiated by trained sleep technicians during stable N2 sleep and delivered in 3-minute epochs separated by 6-minute intervals to enable comparison of PRE, STIM, and POST intervals
Posterior thalamic stimulation (TI-TES)
Device
Stimulation targeted at the posterior thalamus. Within each overnight session, up to 24 stimulation protocols will be administered, randomized across frequencies (including SHAM). Stimulation will be initiated by trained sleep technicians during stable N2 sleep and delivered in 3-minute epochs separated by 6-minute intervals to enable comparison of PRE, STIM, and POST intervals.

Treatment groups

24 Participants

are divided into 1 treatment group

Group A: All ParticipantsExperimental treatment 5 interventions

Trial outcomes