About this trial
The loss of movement and walking ability significantly affects quality of life after spinal cord injury. In addition, bladder dysfunction consistently ranks as one of the top disorders affecting quality of life after spinal cord injury. The overall objective of this study is to demonstrate that epidural stimulation may be a method for improving stepping, standing and bladder function in individuals with spinal cord injury. With the use of epidural stimulation, the investigators propose to investigate how well the participant can stand and walk and how well the participant's bladder can store or hold urine as well as void or empty urine. The results of this study may aid in the development of treatments to help individuals with spinal cord injuries that are unable to stand or walk and have impaired bladder function.
Eligibility criteria
Qualifiers
At least 18 years of age
non-progressive SCI
stable medical condition
Inability to stand and step independently
Disqualifiers
ventilator dependent
untreated painful musculoskeletal dysfunction, fracture or pressure sore
untreated psychiatric disorder or ongoing drug abuse
cardiovascular, respiratory, bladder, or renal disease unrelated to SCI
Trial design
Treatments tested in this trial
- Epidural stimulation + Stand Training
- Epidural stimulation + Step Training
- Epidural stimulation + Bladder Capacity Training
- Epidural stimulation + Bladder Voiding Efficiency Training
Treatment groups
Sponsors and collaborators
Claudia Angeli
Lead sponsor
Kessler Foundation
Sponsor institution
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator