LOng COvid COmorbidities: Endocrine,Metabolic,Neuropsychiatric,Muscle,Cardiovascular,Pulmonary,Dermatologic Dysfunctions

ConditionLong Covid-19
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorFederico II University

About this trial

Considering the compelling amount of studies focused on patients in the active phase of COVID-19 disease and the scarcity of studies focused on patient cured from disease aimed at evaluating the sequelae of SARS-CoV-2 infection, the purpose of the study is to investigate whether in patients recovered from COVID-19 disease, SARS-CoV-2 infection has induced: 1) endocrine-metabolic function damage; 2) neuro-psychiatric damage; 3) muscle damage; 4) pulmonary damage; 5) cardiological damage; 6) venous vascular damage; 7) dermatological damage. Patients will be evaluated at baseline (at discharge from infectious and/or pneumology unit) and after 3- 12 months. A better definition of the prevalence and type of sequelae after recovery from COVID-19 disease could significantly improve the therapeutic management and long-term follow-up of these patients, with a relevant impact in terms of health resources and public health.

Eligibility criteria

Qualifiers

Patients of both sexes recovered from SARS-CoV-2 infection (two negative nasopharyngeal swabs, negative IgM and positive anti SARS-CoV-2 IgG);

Aged over 18 years of age;

Ability to understand protocol procedures

Disqualifiers

Any psychological/psychiatric/other medical conditions compromising the understanding of the nature and purpose of the study, and of its possible consequences

uncooperative attitude of the patient

Trial design

Treatments tested in this trial

  • Assessments of endocrinological phenotypes of LO-COCO patients
  • Assessment of muscular phenotypes of LO-COCO patients
  • Assessment of neuropsychiatric phenotypes of LO-COCO patients
  • Muscle biopsy
  • Assessment of pulmonary phenotypes of LO-COCO patients
  • Assessment of cardiological phenotypes of LO-COCO patients
  • Assessment of vascular phenotypes of LO-COCO patients
  • Assessment of dermatological phenotypes of LO-COCO patients
  • Tissue biopsy

Treatment groups

No treatment groups listed

Sponsors and collaborators

Federico II University

Lead sponsor

Azienda Sanitaria Locale Napoli 2 Nord

Collaborator