Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorNantes University Hospital

About this trial

The HOMI-LUNG - HAP study is part of the HOMI-LUNG project, funded by the Horizon Europe program. The "HOMI-LUNG" project is an international, interdisciplinary project that aims to better understand the causal links between respiratory tract infections (i.e. pneumonia) and the progression of cardiovascular disease. More specifically, the project aims to quantify the burden of cardiovascular disease after pneumonia and assess patients; acceptability of long-term health alterations, as well as to define pneumonia endotypes with distinct pathobiological mechanisms associated with exacerbation of cardiovascular disease.

Eligibility criteria

Qualifiers

Male or female

Hospitalized for acute coronary syndrome for less than 7 days.

Informed consent from the patient

Person insured under a health insurance scheme

Disqualifiers

Groups A, B, C and D

Age <80 years old

Immunosuppression pre-existing to the index hospitalisation, defined as lymphopenia; 500 elements/mm3, haematologic cancer, aplasia, chemotherapy/radiotherapy for cancer within 3 months prior to the inclusion, or anti-graft rejection drug.

Pregnant women, breastfeeding women.

Trial design

Treatments tested in this trial

  • Blood samples
  • Oropharyngeal swabs
  • ECG
  • Cardiopulmonary exercise test, spirometry, plethysmography, pulmonary absorption of carbon monoxide in a single inspiration

Treatment groups

300 Participants
are divided into 4 treatment groups

Sponsors and collaborators