K-CADASIL is a 10-year prospective study of 500 Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a genetic brain disease that causes stroke and dementia. The investigators will track symptoms, brain scans, memory tests, and gene information to understand disease progression in Koreans and identify better treatments. Participants will visit clinics regularly for check-ups and blood tests. This study aims to help improve care for CADASIL patients and families worldwide.
Age ≥ 19 years
CADASIL suspected or confirmed by genetic testing (NOTCH3 mutation)
Able to provide written informed consent (participant or legally authorized representative)
Contraindication to MRI (claustrophobia, metal implants, pacemaker)
Acute ischemic or hemorrhagic stroke within 180 days prior to enrollment
Jeju National University Hospital
Lead sponsor
Asan Medical Center
Collaborator
Chonnam National University Hospital
Collaborator
Chungbuk National University Hospital
Collaborator
Dong-A University Hospital
Collaborator
Ewha Woman University Medical Center
Collaborator
Hallym University Medical Center
Collaborator
Hanyang University Seoul Hospital
Collaborator
Inje University Ilsan Paik Hospital
Collaborator
Kangdong Sacred Heart Hospital
Collaborator
Keimyung University Dongsan Medical Center
Collaborator
Korea University Ansan Hospital
Collaborator
Korea University Guro Hospital
Collaborator
Kyung Hee University Hospital
Collaborator
Kyungpook National University Hospital
Collaborator
Nowon Eulji Medical Center
Collaborator
Pusan National University Hospital
Collaborator
Seoul Medical Center
Collaborator
Seoul National University Bundang Hospital
Collaborator
Seoul National University Hospital
Collaborator
Severance Hospital
Collaborator
Soonchunhyang University Hospital
Collaborator
Ulsan University Hospital
Collaborator
Yeungnam University Hospital
Collaborator
Daejeon Eulji University Medical Center
Collaborator
Jeonbuk National University Hospital
Collaborator
DongGuk University
Collaborator