This study evaluates the effects of 3 years-Tai Chi exercise intervention on cognitive function in subjects with subjective cognitive impairment (SCI). Participants will be randomized into the Tai chi training group and the control group.
Male and female participants aged 60 to 75 years (inclusive) at the time of screening;
Willing and able to give informed consent by GCP and local guidance;
Meets the diagnostic criteria for subjective cognitive impairment (SCI) and the following criteria
Subjective decline in memory, rather than other domains of cognition
Cognitive impairment caused by other reasons (for example) cerebrovascular disease, central nervous system infection, Creutzfeldt-Jakob disease, Huntington's disease, Parkinson's disease, dementia with Lewy bodies, trauma, other physical and chemical factors (drugs, alcohol, CO, etc.), important physical diseases (hepatic encephalopathy, pulmonary encephalopathy, etc.), brain tumor, endocrine diseases (thyroid disease, parathyroid disease), and vitamin deficiency or any other cause of dementia;
Abnormal folate, thyroid, and/or vitamin B12 values that cannot be corrected before baseline visit;
Major structural brain disease as judged by central MRI Diagnostic Imaging Review Team (eg, ischemic infarcts, subdural hematoma, hemorrhage, hydrocephalus, brain tumors, multiple subcortical ischemic lesions. or a single lesion in a critical region [eg, thalamus]). Mild white matter changes without clinical significance and no more than 2 lacunar infarcts are permitted;
Geriatric Depression Scale-15(GDS-15) total score > 7 at screening;
Ruijin Hospital
Lead sponsor
Zhangjiagang Aoyang Hospital of Jiangsu Province
Collaborator