Long-term Remote Ischemic Preconditioning Improves Myocardial Perfusion and Prognosis of Patients After CABG

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorHenan Institute of Cardiovascular Epidemiology

About this trial

Remote Ischemic preconditioning (RIPC) has been reported to improve myocardial microcirculation, promote collateral circulation recruitment, and improve myocardial perfusion in patients.Two large randomized controlled trials demonstrated a perioperative cardioprotective effect of RIPC (reduced troponin levels), but did not find that a single preoperative RIPC improved long-term outcomes of coronary artery bypass grafting(CABG).The effect of a single RIPC before CABG may be too short. This study aims to investigate whether long-term RIPC improved myocardial perfusion in patients 3 months and 6 months after CABG surgery , and to detect changes in blood vascular endothelial growth factor, Nitrc Oxide, adenosine,and Endothelin-1, and to observe MACCE event rates at 12 months.

Eligibility criteria

Qualifiers

Three coronary artery lesions, CABG surgery was planned

Disqualifiers

The patients could not tolerate ripc;

peripheral vascular disease affecting upper limbs

Acute myocardial infarction complicated with cardiogenic shock,in recent 30 days,

Emergency cases

Trial design

Treatments tested in this trial

  • remote ischemic preconditioning (RIPC)

Treatment groups

210 Participants
are divided into 3 treatment groups