Longevity Families of the Netherlands

ConditionsLongevity Familial Longevity Extreme Longevity Aging

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age75+

SponsorLeiden University Medical Center

About this trial

The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity.

The purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity

Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity

Disqualifiers

None

Trial population

Dutch Caucasian descent: Ages 75 and older, with siblings enriched for familial longevity, and individuals without a history of familial longevity

Trial design

Design model

Family-based

Time perspective

Cross-sectional

Treatments tested in this trial

Not listed

Trial groups

600 Participants

are grouped into 2 trial groups

Group A: Cases - Enriched for familial longevity

Group B: Controls - Non-enriched for familial longevity

Trial outcomes

Primary outcomes

Identifying the genetic variants of Familial Longevity

To identify gene variants associated with healthy aging and protection from (multi)morbidity

Time frame

through study completion, an average of 2 years

Secondary outcomes

Studying the environmental factor of Familial Longevity through questionnaires and its interaction with the genetic component

To study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component

Time frame

through study completion, an average of 2 years

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Leiden University Medical Center

Lead sponsor

Jacobijn Gussekloo, Prof. dr.

Collaborator

Simon P. Mooijaart, Prof. dr.