Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-85
SponsorWestern University, Canada
About this trial
This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.
Eligibility criteria
Qualifiers
Patient understands study procedures and is willing to participate in the study as indicated by the patient's signature
Provision of written, informed consent prior to any study specific procedures
Males and females aged 18-85
Current or former cannabis smoker (medicinal or recreational) with or without concurrent tobacco smoking history
Disqualifiers
Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material
Participant is medically unstable in the opinion of the Principal Investigator
Participant has a daytime room air oxygen saturation <90% while lying supine
Participant is unable to perform spirometry or plethysmography maneuvers
Trial design
Treatments tested in this trial
- Hyperpolarized Xenon-129 MRI of the lungs
- Computed Tomography (CT)
- Pulmonary Function Tests (PFTs)
- Six Minute Walk Test (6MWT)
- Cardiopulmonary exercise testing (CPET)
- Sputum analysis
- Blood analysis
Treatment groups
200 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov