Loop Diuretic Therapy in Acutely Decompensated Heart Failure
ConditionAcute Heart Failure
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Siena
About this trial
DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF. Previous pilot study design was planned to anticipate a larger multicenter trial able to definitively evaluate the optimal loop diuretic use strategy in patients with ADHF.
Eligibility criteria
Qualifiers
Patients over 18 years;
Patients with diagnosis of ADHF(dyspnea, orthopnea, peripheral edema or major fatigue and at least two clinical signs including rales, hepatomegaly, pulmonary congestion on chest radiography, jugular vein dilatation, or a third heart sound);
Blood BNP > 100 pg/mL;
Disqualifiers
Patients who receive more than 40 mg of IV furosemide;
End-Stage renal disease or renal replacement therapy;
Recent myocardial infarction (within thirty days of screening);
Systolic blood pressure < 80 mmHg;
Trial design
Treatments tested in this trial
- Continuous Furosemide Infusion
- Intermittent Furosemide Infusion
Treatment groups
370 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Siena
Lead sponsor
University of Roma La Sapienza
Collaborator
Ospedale Regina Montis Regalis
Collaborator
University of Naples
Collaborator
A.O.U. Città della Salute e della Scienza
Collaborator
University of Milan
Collaborator
Source ClinicalTrials.gov