The primary goals of this study are to compare the differences in tissue-resident Treg gene signature for activation, proliferation, and suppressive function using single-cell/-nucleus RNA sequencing in patients treated with ld-IL-2 compared to control grouped by individual tissue beds from in and around the heart. Additionally, tissue-resident Tregs will be compared to peripheral blood Tregs from the same patient to assess the differential effect of ld-IL-2 on the two compartments.
Aged over 18 years old
Undergoing CABG surgery
Critical left main stem coronary disease
Severe valvular disease (for example 'severe' aortic stenosis as classified on echocardiogram report)
Haemodynamic instability caused by arrhythmia requiring cardioversion in the current admission
Non-sustained ventricular tachycardia of >10 beats in the last 48 hours
Cambridge University Hospitals NHS Foundation Trust
Lead sponsor
Royal Papworth Hospital
Collaborator