This study evaluates whether a 7-day ketogenic dietary regimen before 2-\[18F\]FDG PET/CT can improve the diagnostic accuracy of imaging in adults with suspected or histologically confirmed lepidic-predominant lung adenocarcinoma (LPA). LPA frequently shows low glucose metabolism and may yield false-negative FDG PET/CT results. Approximately 30 participants will undergo a tailored ketogenic diet for 7 days before PET/CT. Imaging results will be compared with histopathology and additionally assessed against literature-reported diagnostic performance and a matched retrospective institutional cohort.
Written informed consent.
Age 18 years or older.
CT evidence of a lung nodule suspicious for LPA or lung biopsy positive for LPA.
Target nodule diameter at least 10 mm.
Not suitable for prolonged imaging procedures.
Renal failure.
Type 1 diabetes mellitus.
Pancreatitis.