Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy

ConditionPeriodontitis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age25-70
SponsorUniversity of Ljubljana

About this trial

Periodontal disease is an oral disease characterized by microbially associated, host-mediated inflammation of the periodontium. In the treatment of periodontal disease, conventional periodontal therapy includes both surgical and non-surgical approaches. Non-surgical therapy (i.e. scaling and root planing - SRP) remains an essential part of periodontal therapy. Here, diseased root surface debridement utilizing different hand and ultrasonic instrumentation is performed to facilitate periodontal re-attachment and to reduce the bacterial mass in the periodontal pocket.

In the last decade, the use of lasers (light amplification by stimulated emission of radiation) has occupied part of the dialogue within periodontology due to several proposed advantages. In the arena of periodontology, laser use, as an adjunct to non-surgical therapy, was demonstrated to enhance periodontal healing; however, it is still the matter of debate. Among laser applications, low-level laser therapy is recommended for its pain-reducing, woundhealing and anti-inflammatory effects.

Hyaluronic acid is a non-sulfated glycosaminoglycan and a major component of the extracellular matrix. It is found in various body fluids, such as gingival crevicular fluid, saliva, serum and synovial fluid. Anti-inflammatory, anti-edematous and anti-bacterial activities of hyaluronic acid have been investigated in dentistry, specially in periodontology.

Eligibility criteria

Qualifiers

systemically healthy

nonsmokers

untreated periodontal disease (stage 3, grade B or C)

plaque index will not exceed 20%

Disqualifiers

systemic diseases with impact on periodontal health

medication with impact on periodontal health

smokers

pregnant and lactating women

Trial design

Treatments tested in this trial

  • SRP+LASER (Dentsply Sirona - SIROLaser Blue)
  • SRP+HA
  • SRP

Treatment groups

45 Participants
are divided into 3 treatment groups

Sponsors and collaborators

University of Ljubljana

Lead sponsor

University Medical Centre Ljubljana

Collaborator