Lung Recruitment and PEEP Effects on Intracranial Pressure in Cranial Surgery
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorUniversity of Chile
About this trial
High positive end-expiratory pressure (PEEP) levels required to achieve clinical benefits may increase ICP and reduce cerebral perfusion pressure (CPP) in patients at risk of intracranial hypertension.
However, individualizing ventilation parameters is essential for each patient. Among protective ventilation strategies, PEEP is key to preventing alveolar collapse. The PEEP level that minimizes alveolar collapse while avoiding overdistension of the pulmonary parenchyma is known as the Best PEEP. This study aims to evaluate the application of Best PEEP in cranial neurosurgery.
Eligibility criteria
Qualifiers
ASA classification I-III.
Elective cranial neurosurgery.
Disqualifiers
ASA classification IV or higher.
Documented intracranial hypertension.
Severe pulmonary disease (e.g., asthma, COPD).
Emergency surgery.
Trial design
Treatments tested in this trial
- Subdural pressure measurement
Treatment groups
No treatment groups listed
Sponsors and collaborators
Source ClinicalTrials.gov