About this trial
The goal of this research study is to further understand the physiological mechanisms involved in a heart condition called takotsubo cardiomyopathy, also known as broken heart syndrome. Furthermore, the investigators will be assessing the effects different cardiac medications have on these physiological mechanisms.
This will be achieved by performing cardiac MRI scans using a special dye called manganese. Manganese uptake in the heart is altered in patients with takotsubo cardiomyopathy. The investigators will study the effects that different cardiac medications have on manganese uptake.
Eligibility criteria
Qualifiers
Males and females >18 years of age
Clinical presentation of takotsubo cardiomyopathy
Have capacity to give formal consent
Disqualifiers
Unable to tolerate or contraindication to magnetic resonance imaging
Renal failure (estimated glomerular filtration rate <30 mL/min/1.73 m2) - this would be assessed by performing a blood test
Prior history of cardiomyopathy
Current pregnancy
Trial design
Treatments tested in this trial
- Bisoprolol
- Valsartan
- sacubitril/ valsartan
- Dapagliflozin (10mg Tab)
- No medications
Treatment groups
6
Treatment groupsSee each treatment group below.