Cardiac allograft vasculopathy (CAV) is a common complication affecting heart transplant patients. This condition causes narrowing of the heart arteries leading to graft dysfunction. Surveillance for CAV is vital; however an ideal approach has not been established. The goal of this study is to assess whether noninvasive positron emission tomography (PET) based surveillance is non-inferior to invasive coronary angiography (ICA) surveillance.
Post heart transplant 2-10 years.
Age ≥18 years.
Able to provide informed consent.
Contraindication to dipyridamole due to severe aortic stenosis.
Contraindication to dipyridamole due to 2:1 or greater AV block without pacemaker.
Contraindication to dipyridamole due to severe bronchospasm.
Unable to undergo coronary angiography due to allergy to iodinated contrast.
Ottawa Heart Institute Research Corporation
Lead sponsor
Canadian Institutes of Health Research (CIHR)
Collaborator