About this trial
This study looks at how jaw surgery called maxillomandibular advancement with counterclockwise rotation affects breathing during sleep in people with moderate to severe obstructive sleep apnea who cannot tolerate standard treatments such as Continous Positive Airway pressure treatment. The participants are followed over time to see whether the surgery improves sleep apnea symptoms, daytime sleepiness, and airway size, and whether these improvements last. Advanced three-dimensional imaging and airflow analysis are used to better understand how the surgery changes the airway and breathing. The goal is to evaluate the long-term effectiveness and safety of this surgical treatment.
Eligibility criteria
Qualifiers
Clinical diagnosis of obstructive sleep apnea with AHI ≥15 events/h.
Residence and/or registration in Dalarna County
Body mass index (BMI; kg/m²) between 15 and 35
Documented failure of CPAP or mandibular advancement therapy.
Disqualifiers
Medical conditions contraindicating general anesthesia.
American Society of Anesthesiologists Physical Status (ASA) Class III-VI
Central sleep apnea
Narcolepsy
Trial design
Treatments tested in this trial
- Maxillomandibular advancement surgery with counterclockwise rotation
Treatment groups
Sponsors and collaborators
Jani Talvilahti
Lead sponsor
Dalarna County Council, Sweden
Sponsor institution