Measuring Single Neuron Activity in the Brain
ConditionNeurological Diseases or Conditions
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity College, London
About this trial
The SUNAN (Single Unit Neurophysiological Architecture of the Neocortex) study aims to understand how individual brain cells called neurons interact and communicate, and how the neurons can be affected in neurological disease. Using an advanced digital probe called the "Neuropixels probe," which is as thin as a human hair, the investigators can record electrical activity from individual neurons on the outmost layer of the brain (cerebral cortex). This electrical (neurophysiological) activity recording technique allows the investigators to isolate and monitor single-neuron activity from the human brain during planned neurosurgical operations in real time.
Eligibility criteria
Qualifiers
Aged 18 years and over.
Documented informed consent to participate.
Resected e.g., as removal of part of a tumour or epilepsy focused. Or
Transgressed as part of the surgical approach to reach a deeper target e.g., resection of a deep tumour or cavernoma.
Disqualifiers
Participants who lack the capacity to give informed consent.
Participants who are pregnant or breast feeding at the time of surgery.
Participants deemed to be unsuitable for recruitment to the study by the responsible Consultant Neurosurgeon. If in the view of the treating consultant involvement in the study would compromise the patient's surgery or present an unacceptable risk to them, they will not be recruited to the study. For example, if the participant does not meet the standard of care preoperative checks.
Concern from the Consultant Neurosurgeon or treating Anaesthetist that there would be an unreasonable burden on the patient to participate in the study. For example, risk due to increased length of anaesthetic time.
Trial design
Treatments tested in this trial
- Neuropixels recording intraoperatively during planned neurosurgery
Treatment groups
50 Participants
are divided into 1 treatment groupLocations
Sponsors and collaborators
University College, London
Lead sponsor
Francis Crick Institute
Collaborator
Source ClinicalTrials.gov