Mechanisms of Acute Kidney Injury in Severe Infections
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age30+
SponsorUppsala University Hospital
About this trial
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.
Eligibility criteria
Qualifiers
> 30 years
At least AKI stage 1 according to KDIGO where the last plasma creatinine is measured within 24 hours of the examination
> 30 years
No previously known kidney disease
Disqualifiers
Chronic renal failure (CKD stage >3a) or dialysis
Instability in vital functions that makes PET-CT examination unsuitable
Claustrophobia or other reasons that make the patient unable to lie still during the examination.
Pregnancy and breastfeeding
Trial design
Treatments tested in this trial
- Positron emission tomography (PET)
Treatment groups
15 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov