Mechanisms of Open and Hidden Placebo in Stroke Recovery
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorSpaulding Rehabilitation Hospital
About this trial
This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies.
Eligibility criteria
Qualifiers
Adults with hemiparesis due to chronic stroke
Stroke duration of 6 months or more
Fugl-Meyer scale upper extremity motor assessment score of > 11 and ≤ 56
Pre-stroke disability (defined as a score of < 3 on the Modified Rankin Scale)
Disqualifiers
Stroke of anterior cerebral artery territory with prefrontal lesion and stroke-related decreased EEG power in the prefrontal cortex
Unable to understand instructions
TMS contraindications: electronic hardware in close contact to the discharging coil such as cochlear implant, internal pulse generator or medical pump
Concurrent unstable medical conditions
Trial design
Treatments tested in this trial
- Active rTMS
- Sham rTMS
- Open Placebo
Treatment groups
56 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov