Mechanisms of Pregnancy Vascular Adaptations
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-40
SponsorUniversity of Wisconsin, Madison
About this trial
The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples to study the blood vessels, specifically the expression/activation of the AT2R.
Eligibility criteria
Qualifiers
Female
Ages 18 to 40 years old
Singleton gestation between 28 weeks, 0 days and 41 weeks, 0 days gestational age at the time of consent
Undergoing caesarean section, either planned or otherwise with or without trial of labor
Disqualifiers
Treatment of severe hypertension by antihypertensive or use of magnesium sulfate after the patient is hospitalized for the diagnosis of preeclampsia.
Any major fetal structural anomalies or aneuploidies
Undergoing cesarean section for placental abruption or bleeding complications.
Singleton gestation not within 36 weeks, 0 days and 41 weeks, 0 days gestational age at the time of enrollment (delivery)
Trial design
Treatments tested in this trial
- Omental Biopsy
Treatment groups
166 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Wisconsin, Madison
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Source ClinicalTrials.gov