Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep to Reward- and Stress-Related Brain Function

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-24
SponsorUniversity of Oregon

About this trial

This research will use biobehavioral approaches to generate understanding about the linkages between stressful life events, sleep duration and timing, and alcohol use in young adults, with a long-term aim of developing effective preventative interventions for alcohol use disorders.

Eligibility criteria

Qualifiers

18-24 years of age;

NIAAA criteria for past-month high-risk drinking (i.e., ≥ 4 drinks/day or ≥ 8/week for women, ≥ 5 drinks/day or ≥ 15/week for men);

short and late sleep (weekday sleep duration ≤ 7.5 hours and bedtime ≥ 24:00 (midnight); n=60) or long and early sleep (weekday sleep duration > 7.5 hours and bedtime ≤ 24:00 (midnight); n=30);

at least moderate lifetime exposure to stressors (≥ 2 events on the 20-item Adult Stress and Adversity Inventory-Screener);

Disqualifiers

Severe alcohol use disorder (AUD) and/or substance use disorder (SUD), defined as ≥6 AUD/SUD criteria in the Diagnostic and Statistical Manual-5;

acute alcohol intoxication on the days of the laboratory post-intensive visits, operationalized as a blood alcohol concentration of .02 or higher during Breathalyzer saliva screen;

current clinician-provided diagnosis of narcolepsy or idiopathic hypersomnia;

lifetime diagnosis of bipolar or schizophrenia spectrum disorder;

Trial design

Treatments tested in this trial

  • Sleep extension and advance
  • Regular sleep duration and timing

Treatment groups

90 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University of Oregon

Lead sponsor

University of Pittsburgh

Collaborator

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Collaborator