Mechanisms Preventing Pharyngeal Reflux
ConditionGERD
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-85
SponsorMedical College of Wisconsin
About this trial
The overall goal is to define and characterize the manometric characteristics of UES incompetence associated with objectively documented pharyngeal reflux. The investigators will use endoscopic reflux detection as gold standard.
Eligibility criteria
Qualifiers
Age 18 to 85
GERD patients with complaints of regurgitation and supra-esophageal symptoms will be included and recruited from our GI & Otolaryngology clinics
GERD patients without complaint of supra-esophageal symptoms and regurgitation will be included and recruited from our GI & Otolaryngology clinics
Asthma patients with and without supra-esophageal symptoms will be included and recruited from clinics affiliated with Medical College of Wisconsin. Asthma patients with the following classifications of asthma severity will be included: intermittent, mild persistent, moderate persistent, and severe persistent (as long as no acute asthma exacerbation at the time of the study)
Disqualifiers
Age <18 or >85
Active alcohol or drug abuse
History of ear, nose, throat and pulmonary diseases suspected of being GERD induced
History of head and neck malignancy and chemo-radiation therapy to the head and neck
Trial design
Treatments tested in this trial
- Concurrent manometry/impedance/pH with video pharyngo-laryngoscopy
- Slow and rapid intra-esophageal infusion
Treatment groups
300 Participants
are divided into 5 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov