Mechanisms Underlying the Placebo Effect in Both Histaminergic and Non-histaminergic Itch
ConditionITCH
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorAalborg University
About this trial
The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as depression, anxiety and stress. Afterwards, two areas will be selected on each forearm of the subjects. The four areas will be treated with the same vehicle cream for 20 minutes, in order to test the placebo effect. At the end of the cream application, two areas will be randomly treated with histamine while cowhage will be applied on the other two areas. During the 10 minutes of the application of the pruritogens, itch and pain will be continuously monitored using a Visual Analog Scale.
Eligibility criteria
Qualifiers
Healthy men and women
18-60 years
Speak and understand English
Disqualifiers
Pregnancy or lactation
Drug addiction defined as any use of cannabis, opioids, or other drugs
Previous or current history of neurological, immunological, musculoskeletal, cardiac disorder or psychiatric diagnoses that may affect the results (e.g., neuropathy, muscular pain in the upper extremities, anxiety, depression, schizophrenia, etc.)
Moles, wounds, scars, or tattoos in the area to be treated or tested
Trial design
Treatments tested in this trial
- Histamine
- Cowhage
Treatment groups
30 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov