Mechanistic Insights From Temporary Pacing in HFpEF
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorGuy's and St Thomas' NHS Foundation Trust
About this trial
Heart failure with preserved ejection fraction (HFpEF) is characterised by impaired diastolic function. A recent clinical trial has demonstrated multiple beneficial outcomes in HFpEF patients receiving personalised accelerated pacing from indwelling permanent pacemakers, including symptomatic improvement, objective reductions in NT-proBNP level and AF-burden.
The investigators aim to determine the underlying mechanisms behind these documented effects, to investigate the acute intracardiac haemodynamic response to temporary multisite pacing in HFpEF participants and to gain further mechanistic insight with additional haemodynamic, electrical and echocardiographic data collection during temporary pacing in this cohort. This will all provide valuable information towards new potential targets of therapy.
Eligibility criteria
Qualifiers
Participant is willing and able to give informed consent for participation in the study.
Male or Female, aged 18 years or above.
Formal diagnosis of HFpEF as per ESC guidelines
NYHA grade II-IV heart failure symptoms
Disqualifiers
History of persistent or permanent AF
Permanent pacing device in situ
Female participants who are pregnant, lactating or planning pregnancy during the course of the study.
Scheduled elective surgery or other procedures requiring general anaesthesia during the study.
Trial design
Treatments tested in this trial
- Acute Haemodynamic Study
Treatment groups
10 Participants
are divided into 1 treatment groupLocations
Sponsors and collaborators
Source ClinicalTrials.gov