A varicocele is defined as an abnormal venous dilatation and/or tortuosity of the pampiniform plexus in the scrotum. Although varicoceles are almost always and more common on the left side, up to 50% of the men with varicocele, have bilateral varicoceles.
Varicocele has a negative impact on spermatogenesis, testicular volume, Standard semen parameters, and fertilization, implantation, and embryo outcomes.
Sub-fertile men with clinically palpable varicoceles ( unilateral or bilateral ).
Men with teratozoospermia.
Recurrent varicoceles.
Significant medical diseases as: Hepatic insufficiency.
Hypersensitivity to the drugs.
Female factor of infertility.