About this trial
The goal of this clinical trial is to find out whether removing the fallopian tubes at the time of hysterectomy leads to an earlier menopause. The study includes women under 55 years of age who previously underwent hysterectomy as participants in the HOPPSA trial, where they were randomly assigned to either removal of the fallopian tubes or no removal.
The main question is:
• Does removing the fallopian tubes at the time of hysterectomy lead to an earlier menopause? Researchers will compare women who had their fallopian tubes removed during hysterectomy with women who had hysterectomy alone to see whether menopause occurs earlier after tube removal. Age at menopause will be estimated by measuring follicle-stimulating hormone (FSH) in small blood samples collected on a paper card.
Participants will:
* Collect 4-5 drops of blood using a finger prick * Place the drops on a paper card and mail it to the researchers * Complete an online questionnaire These steps will be done twice, one year apart.
Eligibility criteria
Qualifiers
Having had hysterectomy for a benign indication
Less than 55 years at surgery
Was included in the ITT population of the HOPPSA register-based randomised controlled trial (R-RCT) of opportunistic salpingectomy
Informed consent
Disqualifiers
Ongoing systemic hormonal treatment using sex steroids
Bilateral oophorectomy
Cancer treatment affecting ovarian function
Other treatments with major effects on ovarian function
Trial design
Treatments tested in this trial
- Opportunistic salpingectomy
Treatment groups
Sponsors and collaborators
Umeå University
Lead sponsor
Uppsala University
Collaborator
Karolinska Institutet
Collaborator
Örebro University, Sweden
Collaborator
Queen Mary University of London
Collaborator
Region Västerbotten
Collaborator
Göteborg University
Collaborator