Menopausal Impact of Opportunistic Salpingectomy for Ovarian Cancer Prevention

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age20-65
SponsorUmeå University

About this trial

The goal of this clinical trial is to find out whether removing the fallopian tubes at the time of hysterectomy leads to an earlier menopause. The study includes women under 55 years of age who previously underwent hysterectomy as participants in the HOPPSA trial, where they were randomly assigned to either removal of the fallopian tubes or no removal.

The main question is:

• Does removing the fallopian tubes at the time of hysterectomy lead to an earlier menopause? Researchers will compare women who had their fallopian tubes removed during hysterectomy with women who had hysterectomy alone to see whether menopause occurs earlier after tube removal. Age at menopause will be estimated by measuring follicle-stimulating hormone (FSH) in small blood samples collected on a paper card.

Participants will:

* Collect 4-5 drops of blood using a finger prick * Place the drops on a paper card and mail it to the researchers * Complete an online questionnaire These steps will be done twice, one year apart.

Eligibility criteria

Qualifiers

Having had hysterectomy for a benign indication

Less than 55 years at surgery

Was included in the ITT population of the HOPPSA register-based randomised controlled trial (R-RCT) of opportunistic salpingectomy

Informed consent

Disqualifiers

Ongoing systemic hormonal treatment using sex steroids

Bilateral oophorectomy

Cancer treatment affecting ovarian function

Other treatments with major effects on ovarian function

Trial design

Treatments tested in this trial

  • Opportunistic salpingectomy

Treatment groups

2,100 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Umeå University

Lead sponsor

Uppsala University

Collaborator

Karolinska Institutet

Collaborator

Örebro University, Sweden

Collaborator

Queen Mary University of London

Collaborator

Region Västerbotten

Collaborator

Göteborg University

Collaborator