About this trial
Post-menopausal women who request to begin hormone-replacement therapy (HRT) are directed to the research team. The participants are tested before beginning HRT, after two months of HRT, and five months of HRT. Tests include strength performance, central nervous system functioning, body composition, resting metabolic rate, and vascular screening. The participants are provided a 12-week training intervention (2 x strength, 2 x endurance per week) that can be voluntarily followed between tests at month 2 and 5. Compliance with the training program is recorded. A minimum of 15 participants are needed a priori, but the investigators aim to recruit and test 20 women.
Eligibility criteria
Qualifiers
at least 6 months since their last period but no more than being 5 years post-menopausal
basal follicular-stimulating hormone concentration > 30 IU/L (confirmed post-recruitment)
willing to start combined hormonal treatment
womb and ovaries intact with normal functioning throughout reproductive age
Disqualifiers
classified as excessively obese via BMI assessment (i.e., >35 kg/m2)
intra-uterine device usage during transition to menopause
cardiovascular or skeletomuscular disease preventing strenuous physical activity
smoker
Trial design
Treatments tested in this trial
- Physical training