About this trial
This study, at the Western Human Nutrition Research Center (WHNRC), will focus on whether or not achieving and maintaining a healthy body weight is the most important health promoting recommendation of the Dietary Guidelines for Americans (DGA).The investigators hypothesize that improvement in cardiometabolic risk factors resulting from eating a DGA style diet will be greater in people whose energy intake is restricted to result in weight loss compared to those who maintain their weight. The investigators further propose that during a state of energy restriction, a higher nutrient quality diet such as the DGA style diet pattern, will result in greater improvement in cardiometabolic risk factors compared to a typical American diet (TAD) pattern that tends to be lower nutrient quality (more energy-dense and less nutrient-rich.)
Eligibility criteria
Qualifiers
Body Mass Index (BMI) 23-39.9 kg/m2 or 32-50% body fat percentage
Willingness to have blood drawn
The criteria listed above and at least one of the following: Fasting glucose ≥100 mg/dL but <126 mg/dL or Fasting triglyceride ≥125 mg/dL or HDL-cholesterol ≤50 mg/dL or Blood Pressure (BP): Systolic BP ≥130 mmHg or Diastolic BP ≥85 mmHg or Hemoglobin A1C ≥ 5.7 and <6.5%
Disqualifiers
Active participation in another research study
Tested positive for COVID-19 within the past 10 days
Been in close contact with a COVID-19 positive person within the past 14 days
Blood Pressure (BP): Systolic BP ≥140 mmHg or Diastolic BP ≥90 mmHg
Trial design
Treatments tested in this trial
- DGA Mediterranean diet pattern, energy balance
- DGA Mediterranean diet pattern, negative energy balance
- TAD diet pattern, negative energy balance