The focus of this cross-sectional study is to determine the effects of tissue-specific (adipose tissue or muscle) vs global (combined) insulin resistance (IR) on hepatic triglyceride biosynthesis in humans, and to determine differential effects of an acute exercise intervention on hepatic triglyceride biosynthesis in these groups.
Ability to give informed consent
Overweight, defined as BMI 25-30 kg/m2
Modest hypertriglyceridemia, defined as fasting plasma triglycerides 1.5-3.0mM
High risk of insulin resistance, defined as fasting plasma insulin >64pM
Active or chronic liver disease, kidney disease, congestive heart failure, unstable angina, history of acute cardiovascular events within 6mo of screening, history of seizures or syncope, or an active infection requiring antimicrobial therapy;
Use of insulin, thiazolidinediones, SGLT2 inhibitors, or sulfonylureas;
Use of fibrates, omega 3 (fish oil), niacin, or PCSK9 antagonists;
Use of systemic glucocorticoids within 60d prior to participation;
Yale University
Lead sponsor
Amsterdam UMC
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator