To explore the relationship of treatment-related changes in electrophysiology and those in metabolomics for identification of the underlying metabolic mechanisms for the electrophysiological effects of methylphenidate in children with ADHD.
Patients with ADHD
* Patients, aged 6 to 18 years, meet the DSM-5 diagnostic criteria for ADHD.
At baseline, patients have a Clinical Global Impressions-ADHD-Severity (CGI-ADHD-S) score greater than 4.
Patients have a Full IQ (FIQ) score greater than 80.
Patients have a major psychiatric disorder, such as autism spectrum disorder, schizophrenia, affective disorders, or substance use disorders.
Patients have a major disorder of central nervous system, such as epilepsy.
Patients have a major systemic disease, such as diabetes mellitus or cardiovascular diseases.
Patients have ever received any medication to treat the clinical symptoms of ADHD.