It is uncertain whether intravenous methylprednisolone improves outcomes for acute anterior circulation large vessel occlusion (LVO) patients with a large infarct core. In this study, the investigators hypothesize that methylprednisolone plus endovascular thrombectomy (EVT) might be superior to EVT alone in patients with evidence of a large infarct volume. The primary objective of the study is to establish the efficacy of methylprednisolone with EVT in patients with acute anterior circulation LVO and a large infarct core.
Aged 18 to 85 years;
Clinically diagnosed acute ischemic stroke with screening NIHSS ≥6;
Time from last known well to randomization ≤24 hours;
Pre-stroke mRS score of 0-1;
Intracranial hemorrhage on NCCT or MRI;
Allergy to corticosteroids;
Allergy to contrast agents;
Severe infectious disease unsuitable for corticosteroid therapy or concurrent contraindications to corticosteroid treatment;