The goal of this observational study is to learn about the micro-movements in patients with prolonged disorders of consciousness. The main questions it aims to answer are:
Use the neuropsychological paradigm model to monitor micro-movements, assess the patient's remaining level of consciousness and accurately classify it; screen out patients with cognitive-motor dissociation to improve the prognosis of cognitive function; explore the remaining brain function of patients with chronic disorders of consciousness and promote relevant study of neural mechanisms.
Participants will be subjected to consciousness assessment by CRS-r scale, and their micro-movement changes in response to various emotional stimuli will be captured, along with the collection of EEG and MRI data. Follow-up evaluations will be conducted using the CRS-R scale and GOS scale, with a follow-up period of 6 months.
Patients with consciousness disorders for more than 28 days following severe brain injury, assessed by the CRS-R scale to meet the criteria for VS or MCS;
Aged between 18 and 80 years;
Stable vital signs;
Voluntary participation of family members with signed informed consent;
Locked-in syndrome;
Contraindications for EEG examination;
Contraindications for MRI scanning, such as the presence of internal metallic implants;
Diseases and factors that may affect brain function assessment, such as metabolic disorders, poisoning, shock, etc.
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ChinaFirst Affiliated Hospital of Zhejiang University
Lead sponsor
Hangzhou Mingzhou Brain Rehabilitation Hospital
Collaborator
Zhejiang Provincial Armed Police Corps Hospital
Collaborator