Microfluidic Chip vs Density Gradient Centrifugation on the Euploidy Rate of Pre-implantation Genetic Testing
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeUp to 43
SponsorProfessor Ernest Hung-Yu Ng
About this trial
Infertile women attending for PGT at the Centre of Assisted Reproduction and Embryology, Queen Mary Hospital and Kwong Wah Hospital will be recruited during ovarian stimulation for IVF. Subsequently, they will be randomly assigned on the day of oocyte retrieval by a laboratory staff into one of the following two groups in a 1:1 ratio : (1) the microfluidic chip group and (2) the density gradient centrifugation group for sperm preparation and subsequent use in fertilization. Other IVF procedures will be the same as the standard practice of the Centre. Both women and clinicians will be blinded from the group allocation i.e. a double blind study.
Eligibility criteria
Qualifiers
Women aged <43 years at the time of ovarian stimulation for IVF
Women undergoing PGT for monogenic diseases, structural rearrangement of chromosomes or aneuploidy
Sperm concentration of the raw semen with at least 0.15 million motile sperm per ml or 100 motile sperm per 50 low power field (200x) of observation
Disqualifiers
Use of frozen semen for insemination
Use of donor oocytes and spermatozoa
Submucosal fibroid or hydrosalpinx shown on pelvic scanning and not surgically treated;
Women who had been recruited into this study before and
Trial design
Treatments tested in this trial
- microfluidic chip
- density gradient centrifugation
Treatment groups
318 Participants
are divided into 2 treatment groupsSponsors and collaborators
Professor Ernest Hung-Yu Ng
Lead sponsor
The University of Hong Kong
Sponsor institution
Source ClinicalTrials.gov