Migraine in Adolescents

ConditionMigraine

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age10-13

SponsorWashington University School of Medicine

About this trial

Aim 1. To identify psychophysical and neural factors predicting migraine onset in adolescents

Aim 2a. To determine hormonal, psychophysical, and neural changes associated with migraine onset.

Aim 2b. To identify the temporal relationships between hormonal, psychophysical, and neural changes preceding vs. following migraine onset.

Aim 3. To identify psychophysical and neural factors predicting migraine prognosis in adolescents with migraine.

Eligibility criteria

Qualifiers

Age 10-13

Males or females (biological sex)

Not diagnosed with migraine or having migraine symptoms

With a first degree relative diagnosed with migraine (for the Fam-His group) or without a first or a second degree relative diagnosed with migraine (for the No-Fam-His group)

Disqualifiers

Diagnosis of any chronic pain syndrome

Diagnosis of a neurological, developmental, pubertal, or psychiatric disorder

Taking pain or psychiatric medications regularly

Having an MRI contraindication such as metal in the body or claustrophobia

Trial design

Treatments tested in this trial

MRI
Thermal Stimuli
Pressure stimuli
Pain ratings
Pressure pain thresholds (PPT)
Conditioned pain modulation (CPM) efficiency
Hormonal assessment
Migraine-related measures
Neural assessments
Pubertal status

Treatment groups

250 Participants

are divided into 2 treatment groups

Sponsors and collaborators

Washington University School of Medicine

Lead sponsor

National Institute of Neurological Disorders and Stroke (NINDS)

Collaborator

Source ClinicalTrials.gov