Mind After Midnight
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-55
SponsorUniversity of Arizona
About this trial
This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts. Adults with a history of suicidal ideation in the past six months will complete laboratory and home-based assessments under varying levels of sleep pressure. Participants will be evaluated during late-night wakefulness and under conditions of both higher and lower sleep pressure. The goal of the study is to better understand the biological and behavioral mechanisms that may contribute to elevated suicide risk during nocturnal wakefulness.
Eligibility criteria
Qualifiers
Age 18-55 years
History of suicidal ideation within the past 6 months
Habitual bedtime between 9:00 PM and 1:00 AM
Habitual wake time between 6:00 AM and 9:00 AM
Disqualifiers
Current suicidal intent requiring immediate clinical intervention
Diagnosis of a primary sleep disorder (e.g., untreated obstructive sleep apnea, narcolepsy)
Bipolar disorder or psychotic disorder
Substance use disorder within the past 3 months
Trial design
Treatments tested in this trial
- Sleep Pressure Manipulation
Treatment groups
90 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Arizona
Lead sponsor
National Institute of Mental Health (NIMH)
Collaborator
Source ClinicalTrials.gov