About this trial
Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.
Eligibility criteria
Qualifiers
Healthy older (60+ y) Veteran women and men in the Denver Metro Area
Normally active (e.g., recreational cycling or walking exercise)
Disqualifiers
Impaired renal function, defined as an eGRF of <60 mL/min/1.73m2
Hepatobiliary disease, defined as liver function tests (AST, ALT) >1.5 times the upper limit of normal
Thyroid dysfunction, defined as an ultrasensitive thyroid stimulating hormone (TSH) <0.5 or >5.0 mU/L
Serum Ca <8.5 or >10.3 mg/dL
Trial design
Treatments tested in this trial
- 10 Weeks of Supervised Resistance Exercise Training
- 10 Weeks of Supervised Endurance Exercise Training
Treatment groups
Sponsors and collaborators
VA Office of Research and Development
Lead sponsor
University of Colorado, Denver
Collaborator