Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age25-59
SponsorWake Forest University Health Sciences
About this trial
This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.
Eligibility criteria
Qualifiers
verified HIV status
Current marijuana use (MJ+ groups only)
No current marijuana use (MJ- groups only)
current engagement in HIV care (HIV+ participants only)
Disqualifiers
Lifetime abuse for any illicit drug other than marijuana
<9th grade education; illiteracy or lack of fluency in English
history of moderate or severe head trauma
unstable or serious neurological disorders
Trial design
Treatments tested in this trial
- Multimodal, multi-parametric MRI
- Immune and cytokine profiling
- Neuropsychological testing
Treatment groups
220 Participants
are divided into 4 treatment groupsSponsors and collaborators
Wake Forest University Health Sciences
Lead sponsor
National Institute on Drug Abuse (NIDA)
Collaborator
Source ClinicalTrials.gov