Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeUp to 80
SponsorVA Office of Research and Development
About this trial
The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery.
Eligibility criteria
Qualifiers
U.S. Veteran
Self-reported COVID-19 naïve or COVID-19 > 90 days ago for lean and obese PCC naïve or documented COVID-19 for the lean and obese PCC groups (At least one PCC symptom >4 weeks)
Body Mass Index: 19-25 or 30-50 kg/m2
Disqualifiers
Neurologic, musculoskeletal, or other condition that limits subject's ability to complete study physical assessments
Active inflammatory, COVID-19, autoimmune, infectious, hepatic (LFTs > 2.5 x WNL), renal (eGFR<45), gastrointestinal, malignant, and psychiatric disease
Uncontrolled diabetes (HbA1c >10% or the current use of insulin)
Weight change within the past month of >5 kg
Trial design
Treatments tested in this trial
- 12-weeks of Weight Loss
- 12-weeks of Weight Stability
Treatment groups
150 Participants
are divided into 2 treatment groupsSponsors and collaborators
VA Office of Research and Development
Lead sponsor
Baltimore VA Medical Center
Collaborator
South Texas Veterans Health Care System
Collaborator
Source ClinicalTrials.gov