Children with kidney failure have markedly increased mortality and face repeated transplantation over their lifetime due to limited allograft half-life (12-15 years). Current biopsy-based diagnoses of rejection (using Banff 2022 criteria) suffer from variability and limited sensitivity. PANDA-Kids-ATLAS will analyze up to 600 pediatric FFPE kidney biopsies across multiple centres using the Banff Human Organ Transplant (B-HOT) NanoString panel to develop and validate molecular classifiers of AMR, TCMR and related phenotypes. A secure REDCap database will integrate molecular, pathological and clinical data, aiming to improve early detection, personalize therapy, and enhance long-term graft survival and patient quality of life.
Age ≤ 21 years
Single kidney transplant recipients (deceased or living donor)
Written informed consent from patients/guardians
Multi-organ transplantation history
Biopsies with insufficient tissue
Paris Translational Research Center for Organ Transplantation
Lead sponsor
Paris Cardiovascular Research Center (Inserm U970)
Collaborator