About this trial
150 males and 150 females ages 14-17 years-old will be enrolled in an observational, longitudinal study. There are three planned in-person visits: a baseline assessment, an 18-month follow-up, and a 36-month follow-up. The in-person visits will include assessment of substance use and other individual differences (e.g., reward function, psychiatric history), neuromelanin-sensitive MRI, as well as functional brain activation collected while the participant is at rest (resting-state fMRI) and while the participant completes a Monetary Incentive Delay task. Subjects will also be asked to complete past 90-day substance use assessments remotely every 90 days for 36 months.
Eligibility criteria
Qualifiers
Males and females ages 14-17 years-old;
English-speaking for assent and interview completion;
Capacity to provide assent.
For parents, the inclusion criteria will be willing and capacity to provide parental permission/consent.
Disqualifiers
current (within 6 months) use of medication that may affect cerebral function
history of severe medical or neurological illness, including stroke or seizure;
history of head trauma with loss of consciousness;
presence of metal in the body;
Trial design
Treatments tested in this trial
- Monetary Incentive Delay Task