Monitoring Treatment Response With On-board DWI During Neo-adjuvant Chemo-radiation for Rectal Cancer Using Magnetic Resonance-guided-radiotherapy Systems

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorInstitut Paoli-Calmettes

About this trial

feasibility of using a diffusion sequence of a MRgRT system as an early marker of treatment response during nRCT of rectal adenocarcinoma.

Eligibility criteria

Qualifiers

Patient over 18 years old.

Diagnosis of histologically confirmed rectal adenocarcinoma for which nRCT has been indicated.

Karnofsky Index (KPS) ≥ 70 or ECOG = 0 or 1

Signed consent to participation.

Disqualifiers

Predominant mucinous component on initial MRI, biopsy and / or definitive pathology. Mucin may lead to overestimation of ADC values on DWIs.

Contraindications to the MRI procedure (non compatible pacemaker or other metallic foreign body, severe claustrophobia).

Exclusive radiation therapy.

Other associated neo-adjuvant treatment.

Trial design

Treatments tested in this trial

  • MRI-guided radiotherapy by on-board DWI sequences

Treatment groups

39 Participants
are divided into 1 treatment group

Sponsors and collaborators

Institut Paoli-Calmettes

Lead sponsor

University of California, Los Angeles

Collaborator