Monotherapy vs Combination Therapy for Bone Infections Caused by Pseudomonas Aeruginosa
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCentre Hospitalier de Saint-Denis
About this trial
This study looks at how well one antibiotic (monotherapy) works compared to two antibiotics (combination therapy) in treating bone infections caused by Pseudomonas aeruginosa. It includes 300 adult patients who had this type of infection confirmed by lab tests and medical imaging. The goal is to find out if using just one antibiotic is as effective as using two, while also looking at side effects, the need for more surgery, antibiotic resistance, and overall antibiotic use.
Eligibility criteria
Qualifiers
Adult patients (≥18 years old)
Diagnosis of osteitis or osteomyelitis due to Pseudomonas aeruginosa
Isolation of Pseudomonas aeruginosa from at least one deep, sterile sample (e.g., bone biopsy, joint aspiration)
Imaging findings consistent with osteomyelitis (MRI, CT scan, or X-ray)
Disqualifiers
No isolation of Pseudomonas aeruginosa
No imaging evidence suggestive of osteomyelitis
Patients under 18 years of age
Trial design
Treatments tested in this trial
- Not listed
Trial groups
No trial groups listed
Sponsors and collaborators
Source ClinicalTrials.gov