Health TrialsbyHealthPanel

Morning Versus Evening Patching in Childhood Amblyopia

ConditionAmblyopia
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age4-8
SponsorYarmouk University

About this trial

To determine whether the time of day at which daily occlusion (patching) is administered - morning (08:00-10:00) versus evening (17:00-19:00) - affects the amount of visual-acuity improvement in the amblyopic eye in children with unilateral amblyopia.

Rationale:

While occlusion therapy remains the mainstay for treatment of childhood amblyopia, existing trials have focused on patching duration, not on the timing of occlusion. Diurnal or chronobiological factors - such as fluctuations in neuroplasticity, attention, compliance, or visual demand during the day - may influence the efficacy of patching. Understanding whether timing matters could help optimize occlusion therapy, improve outcomes, and reduce treatment burden.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age: 4-8 years.

Unilateral amblyopia.

Amblyopic-eye BCVA decimal 0.17-0.67 (≈ 6/36-6/9).

Fellow-eye BCVA ≥ 0.80 decimal (≈ 6/7.5 or better).

Disqualifiers

Bilateral amblyopia.

Sensory-deprivation amblyopia (e.g., due to congenital cataract, ptosis, corneal opacity).

Ocular surgery within the past 6 months, or planned surgery during study.

Likely poor adherence (e.g., due to social, logistic, or family constraints).

Trial design

Design model

Parallel

Treatments tested in this trial

  • eye-patching

    Behavioral

    is a non-invasive treatment for Amblyopia ("lazy eye") in children. It involves covering (patching) the stronger, "good" eye so that the weaker (amblyopic) eye is forced to work. This encourages the brain to rely on the amblyopic eye, helping to strengthen its visual pathways.

Treatment groups

100 Participants
are divided into 2 treatment groups
Group A: Morning patchingExperimental treatment 1 intervention
Group B: Evening patchingExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change in best-corrected visual acuity (BCVA) of the amblyopic eye

Change in best-corrected visual acuity (BCVA) of the amblyopic eye from baseline to month 6, measured using a standardized logMAR (crowded) chart under full refractive correction, by a masked examiner.

Time frame
6 month

Secondary outcomes

1

stereoacuity

Change in stereoacuity (arc-seconds unit) from baseline to Month 6 in amblyopic eye in the trial measured using the Titmus Fly Test

Time frame
6 month

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Yarmouk University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: