Morning Versus Evening Patching in Childhood Amblyopia
ConditionAmblyopia
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age4-8
SponsorYarmouk University
About this trial
To determine whether the time of day at which daily occlusion (patching) is administered - morning (08:00-10:00) versus evening (17:00-19:00) - affects the amount of visual-acuity improvement in the amblyopic eye in children with unilateral amblyopia.
Rationale:
While occlusion therapy remains the mainstay for treatment of childhood amblyopia, existing trials have focused on patching duration, not on the timing of occlusion. Diurnal or chronobiological factors - such as fluctuations in neuroplasticity, attention, compliance, or visual demand during the day - may influence the efficacy of patching. Understanding whether timing matters could help optimize occlusion therapy, improve outcomes, and reduce treatment burden.
Eligibility criteria
Qualifiers
Age: 4-8 years.
Unilateral amblyopia.
Amblyopic-eye BCVA decimal 0.17-0.67 (≈ 6/36-6/9).
Fellow-eye BCVA ≥ 0.80 decimal (≈ 6/7.5 or better).
Disqualifiers
Bilateral amblyopia.
Sensory-deprivation amblyopia (e.g., due to congenital cataract, ptosis, corneal opacity).
Ocular surgery within the past 6 months, or planned surgery during study.
Likely poor adherence (e.g., due to social, logistic, or family constraints).
Trial design
Treatments tested in this trial
- eye-patching
Treatment groups
100 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov