The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.
For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin.
For controls: matched to a case on age (±5 years) and sex
Neurodegenerative or inflammatory neurological pathology
Clinical depressive syndrome
High doses of opioid treatment (greater than 100 mg/day of morphine equivalent)
Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks
The study will be proposed to patients followed at the pain treatment center or in neurosurgery for chronic neuropathic pain, of peripheral or central origin. Controls will be recruited among the patients' companions and the staff of the Adolphe de Rothschild Foundation Hospital.
Case-control
Cross-sectional
reward learning task
Other interventionduring usual follow-up patients will complete a remard learning task questionnaire. This questionnaire cannot be assimilated to a clinical intervention.
To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population
the reward learning ability will be assessed using a specific task. The result of the task questionnaire is a numeric score.
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