The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.
For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin.
For controls: matched to a case on age (±5 years) and sex
Neurodegenerative or inflammatory neurological pathology
Clinical depressive syndrome
High doses of opioid treatment (greater than 100 mg/day of morphine equivalent)
Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks