About this trial
The purpose of this research study is to examine the effect of a brain stimulation training to improve the function of brain-spinal cord- muscle connections. Because brain-to-muscle pathways are very important in our movement control, restoring function of these pathways may improve movement problems after injuries. Spinal cord injury causes damage to the brain-to-muscle connection. However, when the injury is "incomplete", there is a possibility that some of the brain-to-muscle pathways are still connected and may be trained to improve movement function. For examining brain-to-muscle pathways, investigators use a transcranial magnetic stimulator. Investigators hope that the results of this research study will help us develop new treatments for people who have movement disabilities. This study will require about 42 visits over the first 14 weeks, and another 6 visits over an additional 3 months. Each visit will take about 1 ½ hours.
Eligibility criteria
Qualifiers
Adult (≥18 yrs old)
a history of injury to spinal cord at or above C6
neurologically stable (>1 year post SCI)
medical clearance to participate
Disqualifiers
motoneuron injury
unstable medical condition
cognitive impairment (because the studied intervention is a learning-based intervention)
a history of epileptic seizures
Trial design
Treatments tested in this trial
- Motor Evoked Potential (MEP) Operant Conditioning
Treatment groups
Sponsors and collaborators
Medical University of South Carolina
Lead sponsor
Northwestern University
Collaborator
National Institutes of Health (NIH)
Collaborator
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborator