Motoneuron Recruitment and Motor Evoked Potential Up-Conditioning (MEP) in Spinal Cord Injury (SCI)

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorMedical University of South Carolina

About this trial

The purpose of this research study is to examine the effect of a brain stimulation training to improve the function of brain-spinal cord- muscle connections. Because brain-to-muscle pathways are very important in our movement control, restoring function of these pathways may improve movement problems after injuries. Spinal cord injury causes damage to the brain-to-muscle connection. However, when the injury is "incomplete", there is a possibility that some of the brain-to-muscle pathways are still connected and may be trained to improve movement function. For examining brain-to-muscle pathways, investigators use a transcranial magnetic stimulator. Investigators hope that the results of this research study will help us develop new treatments for people who have movement disabilities. This study will require about 42 visits over the first 14 weeks, and another 6 visits over an additional 3 months. Each visit will take about 1 ½ hours.

Eligibility criteria

Qualifiers

Adult (≥18 yrs old)

a history of injury to spinal cord at or above C6

neurologically stable (>1 year post SCI)

medical clearance to participate

Disqualifiers

motoneuron injury

unstable medical condition

cognitive impairment (because the studied intervention is a learning-based intervention)

a history of epileptic seizures

Trial design

Treatments tested in this trial

  • Motor Evoked Potential (MEP) Operant Conditioning

Treatment groups

15 Participants
are divided into 1 treatment group

Sponsors and collaborators

Medical University of South Carolina

Lead sponsor

Northwestern University

Collaborator

National Institutes of Health (NIH)

Collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Collaborator