Motor Evoked Potential and Cortical Silent Period in Migraine
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorIstanbul Gelisim University
About this trial
The primary objective of this study is to assess the level of inhibitory control in the motor cortex of migraine patients using objective and non-invasive methods. To this end, Motor Evoked Potential (MEP) and Cortical Silence Period (CSP) parameters obtained using Transcranial Magnetic Stimulation (TMS) will be measured and comparisons will be made between migraine patients and healthy controls. Since CSP duration is used specifically in the evaluation of GABA-B-mediated inhibitory mechanisms, it has the potential to directly measure the effect of migraine on cortical inhibition.
Eligibility criteria
Qualifiers
Age 18-45 years.
Right-handed individuals.
Migraine patients: diagnosed according to International Headache Society (IHS) criteria.
Healthy controls: no history of migraine or other neurological disorders.
Disqualifiers
History of epilepsy or other seizure disorders.
Presence of metal implants, pacemakers, or other contraindications to TMS.
Pregnancy or breastfeeding.
History of significant neurological or psychiatric disorders.
Trial design
Treatments tested in this trial
- Transcranial Magnetic Stimulation (TMS)
- Surface Electromyography (sEMG)
- Needle EMG / Single Motor Unit (SMU) Recording
Treatment groups
20 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov