MRE for Assessment of Histopathological Growth Patterns in Colorectal Liver Metastases
ConditionMetastatic Colorectal Cancer
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorShengjing Hospital
About this trial
The goal of this study is to investigate the value of MR elastography-based SII as a means of detecting HGP noninvasively in patients with pathology-proven CRLM. MRE will provide a direct measure of tumor-liver adhesion to investigate the relationship between imaging findings and pathophysiological changes in the Liver.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Diagnosed CRLM
Pathologic results obtained in surgical patients
No contraindications for magnetic resonance imaging examination
Disqualifiers
Image quality does not meet the measurement requirements.
the diameter of CRLM <1cm
Combined with other important organ dysfunction
Combined with malignant tumor
Trial population
Study subject inclusion criteria were adult patients with CRLM.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Magnetic Resonance Elastography and routine MRI
Diagnostic testAssessed boundary conditions through MRE-base SII before surgery and recorded HGP of tumor after surgery.
Treatment groups
50 Participants
are divided into 1 treatment groupGroup A: Experimental: Diagnostic (MRE)1 intervention
Trial outcomes
Primary outcomes
1
Radiological assessment of CRLM
Examinations were performed on a 3.0T MRI. Mechanical vibration frequencies of 30 and 60 Hz were applied in synchrony with the MRE pulse sequence. Regions of interest (ROIs) were placed manually in the liver. The performance of the use of SII to predict HGP of tumor was evaluated with the Wilcoxon rank sum, 1-way ANOVA, and Tukey-Kramer tests.
Time frame
Baseline to 6 weeksSponsors and contacts
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Source ClinicalTrials.gov