MRI Assessment of Lung Airways in Cystic Fibrosis: Evaluate MRI's Ability to Detect Changes in Airway Structure .

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age6-18
SponsorThe Hospital for Sick Children

About this trial

This study is being done to determine whether MRI can produce high quality lung and airway images in healthy and CF patients and if MRI can be used to evaluate size and shape of the airways with computer assistance. This study will also repeat MRI experiments two years after the initial MRI scan to see if changes to airway size and shape are seen over time. In a subset of participants, we will investigate whether MRI results are repeatable and reproducible in the short-term one week after the initial MRI visit. This study will help understand if MRI based measurements of airway size and shape can be used as a monitoring tool that does not use x-ray radiation in patients with CF.

Eligibility criteria

Qualifiers

Participants must be greater than or equal to 6 years of age and not greater than 18 years of age.

Informed consent by patient or parent/guardian consent and participant assent when appropriate.

Able to perform reproducible spirometry

Disqualifiers

Medical instability that would preclude the ability to undergo the required investigations

FEV1 % predicted < 40%

Severe claustrophobia

Does not meet MRI screening criteria

Trial design

Treatments tested in this trial

  • Advanced ultrashort echo time (UTE) MRI - Ultrashort echo time (UTE) imaging is a technique that can quickly capture the fast-decaying 1H lung signal.
  • Multiple Breath Wash out (MBW)

Treatment groups

76 Participants
are divided into 2 treatment groups

Sponsors and collaborators