Multi-Center Registry Cohort Study on Prognostic Factors and Prediction Model Construction in Aneurysmal SAH

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorSecond Affiliated Hospital of Nanchang University

About this trial

PROSAH-MPC, a collaborative research project among neurosurgical centers in China, focuses on aneurysmal subarachnoid hemorrhage (aSAH). Its aim is to identify prognostic factors and develop robust prediction models for complications, disability, and mortality in aSAH patients. By leveraging a large, multi-center, prospective cohort design, PROSAH-MPC aims to overcome limitations of past studies and provide a more comprehensive understanding of the disease.

Eligibility criteria

Qualifiers

Subarachnoid hemorrhage confirmed by computed tomography (CT);

Cerebral angiography (CTA) and digital subtraction angiography (DSA) examination confirming intracranial aneurysm rupture as the cause of the subarachnoid hemorrhage;

Blood routine, biochemical function, blood coagulation function, and craniocerebral CT performed within 24 hours of symptom onset;

Underwent aneurysm clipping by surgery or endovascular embolization within 72 hours after-onset.

Disqualifiers

Aneurysm rupture bleeding time exceeding 24 hours before hospital admission;

Incomplete image data or blood test information;

Long-term use of anticoagulant medications such as aspirin or warfarin;

Admitted to hospital with active infectious diseases;

Trial design

Treatments tested in this trial

  • Machine Leaning Models

Treatment groups

5,000 Participants
are divided into 1 treatment group

Sponsors and collaborators

Second Affiliated Hospital of Nanchang University

Lead sponsor

Panzhihua Central Hospital

Collaborator

Zhujiang Hospital

Collaborator

Southwest Hospital, China

Collaborator

Renmin Hospital of Wuhan University

Collaborator